Preparation and Biological Evaluation of Tc-TMPP as a Novel Agent for Tumor Diagnosis
نویسندگان
چکیده
TMPP (5, 10, 15, 20 tetrakis {4-methoxyphenyl} 21H, 23H porphyrin) was labeled with technetium-99m via direct labeling technique using stannous chloride as a reducing agent. The optimum conditions that gave high labeling yield (95.2%) of Tc-TMPP complex were achieved by using 3mg TMPP, 100g SnCl2.2H2O, at pH 3 and 30min reaction time. Accumulation of Tc-TMPP complex was studied in tumor bearing mice . After intravenous injection of Tc-TMPP complex, tumor radioactivity uptake was high compared to normal muscle uptake and it was 7.76 folds after 30 min. Tumor to blood ratio was 2.36 after 30 min.
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